副教授

许璇

职称:副教授

学历:博士

邮箱:xuxuan@ahmu.edu.cn

地址:合肥市瑶海区唐河路,威廉体育东校区,尚学西楼

个人简介
个人简介:
2023.07-至今 威廉体育,校聘副教授
2020.09-2023.06 华中农业大学,生物信息学,博士
2018.09-2020.06 华中农业大学,生物信息学,硕士
2014.09-2018.06 华中农业大学,生物信息学,学士

个人荣誉及学术任职
2023届 华中农业大学优秀博士毕业生
2023届 华中农业大学优秀博士毕业论文
2022年 华中农业大学博士国家奖学金
科研领域
1. 系统遗传学与系统医学:致力于解析生物医学多组学数据并挖掘病理机制,结合机器学习算法构建精准医疗模型,筛选疾病相关的生物标志物,为个体化治疗提供数据和方法支持。
2. 药物发现:专注于神经退行性疾病、精神类疾病、免疫类疾病和病毒性疾病的药物靶点筛选,通过组学数据预测药物的疗效,推动药物重定位研究,旨在缩短药物研发周期,降低研发成本与风险。
代表性成果

1. Xu X, Wang H, Bennett DA, Zhang QY, Meng XY, Zhang HY*. Characterization of brain resilience in Alzheimer's disease using polygenic risk scores and further improvement by integrating mitochondria-associated loci. J. Adv. Res. 2024, 56:113-124.

2. Fan, S.S#., Xu, X#., Luo, Y.B., Meng, X.Y., Liu, Y. GM-CSF+ Th: a central player in autoimmunity. Theranostics, 2025, 15(18), 9944-9968.

3. Xu Xuan*; Li, Jiang, Wang Fei, Xue, Ke, He, Junwen, Xiang-Yu Meng, Yin Shen*. Genetic and pathway complexity in Alzheimers disease: Insights from multi-omic data about the immune response and mitochondrial function. Neural Regeneration Research, 2025, September 29.

4. Xuan Xu*,#, Sha-Sha Fan#, Jiang Li, Hao Wu, Junwen He, Yang He, Xiang-Yu Meng* and Yin Shen*. Integrated Multi-Omics Analysis and Cross-Model Validation Reveal Mitochondrial Signatures in Alzheimers Disease. CNS Neuroscience & Therapeutics, DOI:10.1111/cns.70634

5. Du, Y., Fan, S.-S., Wu, H., He, J., He, Y., Meng, X.-Y*., Xu, X*. Convergent and Divergent Mitochondrial Pathways as Causal Drivers and Therapeutic Targets in Neurological Disorders. Curr. Issues Mol. Biol. 2025, 47, 636.

6. Fei Wang; Jiaqi Wang; Tong Chen; Shuaibin Wang; XiangYu Meng; Yin Shen*; Xuan Xu*; Systematic Identification of Mitochondrial Signatures in Alzheimer’s Disease and Inflammatory Bowel Disease, Mol. Neurobiol. 2025

7. Xu X*, Wang JQ, Chen T, Wang SB, Wang F, He JW, Meng X-Y, Shen Y*. Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma. Front. Aging Neurosci. 2025, 17.

8. Xu X, Wang H, Zhang QY, Xiang-Yu M, XinXing L, Zhang HY*. Dissecting mitochondrial mechanism of Alzheimer’s Disease using gene dependency network and implications for prevention strategies. J Alzheimers Dis. 2023;95(4):1709-1722.

9. Xu X, Wang H, Bennett DA, Zhang QY, Wang G, Zhang HY*. Systems Genetic Identification of Mitochondrion-Associated Alzheimer's Disease Genes and Implications for Disease Risk Prediction. Biomedicines. 2022 Jul 24;10(8):1782.

10. Xu X#, Zhang QY#*, Chu XY, Quan Y, Lv BM, Zhang HY*. Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge. Viruses. 2021 Oct 20;13(11):2117.

11. Xu X, Zhang HY*. The Immunogenetics of Psoriasis and Implications for Drug Repositioning. Int J Mol Sci. 2017 Dec 8;18(12):2650.

12. Ye C-Q, Leng J, Jin M-Y, Meng Y-D, Zhao Z-Y, Meng F-X, Xu X, Fan S-S, Luo H-B, Meng X-Y. SysNatMed: rational natural medicine discovery by systems genetics[J]. Front. Pharmacol. 2025, 16.

13. Li X, Huang W, Xu X, Zhang HY, Shi Q*. Deciphering tissue heterogeneity from spatially resolved transcriptomics by the autoencoder-assisted graph convolutional neural network. Front Genet. 2023 May 25;14:1202409.

14. Wu N*, Xu X, Wang B, Li XM, Cheng YY, Li M, Xia XQ, Zhang YA. Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish. Fish Shellfish Immunol. 2020 Feb;97:204-215.

15. Wang H, Wang G, Zhu LD, Xu X, Diao B, and Zhang HY*. Subnetwork identification and chemical modulation for neural regeneration: A study combining network guided forest and heat diffusion model. Quantitative Biology 2018, 6: 321-333.

16. Wu N, Wang B, Cui Z-W, Zhang X-Y, Cheng Y-Y, Xu X, Li X-M, Wang Z-X, Chen D-D, Zhang Y-A. Integrative transcriptomic and microRNAomic profiling reveals immune mechanism for the resilience to soybean meal stress in fish gut and liver[J]. Front. Physiol. 2018, 9.

17. 陈魏红,麦可,许璇,刘子玄,张红雨,彭辉. 一种胶质细胞偶联人工神经网络模型. 小型微型计算机系统. 2022. 




(二)专利:


1. 张红雨,全源,王晖,朱丽达,许璇,杨庆勇,黄清,一种基于热扩散网络的药物发现方法及其应用,中国发明专利,专利号:ZL201710917312.2,2019年9月授权。


2. 张红雨,褚欣奕,许璇,吕博敏,张青叶,黄清,Nrf2激动剂在制备治疗银屑病的药物中的应用,中国发明专利,专利号:ZL201711323296.0, 2020年7月授权。


3. 张红雨,彭辉,陈魏红,麦可,刘子玄,许璇. 一种人工神经元-胶质细胞网络优化方法及装置,中国发明专利,申请号:202111487637。


研究课题
1.安徽省省自然青年项目(C类),2025/9-2027/9,主持.
2.威廉体育高层次引进人才博士科研启动经费,2023/9-2028/9, 主持.

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